距骨多糖（APS）和距骨类黄酮（AF）对活体外正常老鼠细胞和瘤变老鼠细胞的淋巴细胞繁殖及T—淋巴细胞亚群的影响

作者研究了距骨多糖（APS）和距骨类黄酮（AF）对外活体老鼠细胞和瘤变老鼠细胞的淋巴繁殖和T-淋巴细胞亚群的影响，结果表明：在正常的老鼠细胞中，单独加入APS能诱导非活性的淋巴细胞进行繁殖，而且对于由Con A（伴刀豆球蛋A）激活的淋巴细胞，在加入APS后，繁殖速率加快；单独加入AF不能诱导非活性的淋巴细胞进行繁殖，但是AF能加速的Con A激活的淋巴细胞进行繁殖，在瘤变的老鼠细胞中，由Con A激活的淋巴细胞繁殖速率下降，但当分别加入APS和AF后，繁殖速率得到提高，因此作者认为：不论是正常的老鼠细胞中还是在瘤变的老鼠细胞中，单独使用APS或是一起使用APS与Con A，都能引起T-淋巴细胞总数的增加，并且能使不稳定CD4^ /CD8^ 比率趋于正常化；一起使用AF与Con A时，也具有相同的效应。

THE REGULATING EFFECTS OF ASTRAGALUS POLYSACCHARIDE(APS) AND ASTRAGALUS FLAVONOIDS (AF) ON LYMPHO-PROLIFERATION AND TLYMPHOCYTES AND THEIR SUBPOPULATION IN NORMAL AND TUMORBEARING MICE RESPECTIVELY IN VITRO

The regulating effects of astragalus polysaccharide(APS)and astragalus flavonoids(AF)on lympho-proliferation and T-lymphocyte subset of normal and tumor-bearing mice in vitro has been studied. Experimental results indicated that the APS to be used alone could induce inactivated lymphocytes to proliferate, but proliferation of lyphmocytes activated by Con A is obviously increased after treatment with APS. Although the AF to be used alone could not induce inactivated lymphocytes to proliferate, it could improve lympho-proliferation activated by Con A. The results showed that the reaction of lympho-proliferation activated by Con A was decreased in tumor bearing mice, both APS and AF had improved effects. It was observed that APS to be used alone or combined with Con A can cause increase of total T-lymphocytes in normal and tumor-bearing mice. The imbalance of ratio of CD4 /CD8 can be regulated to normal. AF combined with Con A has same effectiveness.