| 人体肠道微生物对十溴联苯醚的代谢研究 |
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| 引用本文： | 张东平,张帆,余应新,吴明红,盛国英,傅家谟.人体肠道微生物对十溴联苯醚的代谢研究[J].科学通报,2011,56(25):2139-2145. |
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| 作者姓名： | 张东平 张帆 余应新 吴明红 盛国英 傅家谟 |
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| 作者单位： | 上海大学环境与化学工程学院环境污染与健康研究所;上海大学环境与化学工程学院上海射线应用研究所;中国科学院广州地球化学研究所有机地球化学国家重点实验室; |
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| 基金项目： | 国家自然科学青年基金(20807026); 上海市重点学科(S30109)资助项目 |
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| 摘 要： | 十溴联苯醚(BDE209)是一种具有持久性有机污染物特征的溴系阻燃剂, 可在生物体代谢生成更高毒性的化合物. 本文利用从人体粪便中提取的微生物以及通过人体肠道微生态系统模拟装置培养的人体肠道微生物, 在体外条件下研究BDE209 在人体肠道微生物作用下的代谢. 结果表明在为期10 d 的反应时间里, BDE209 含量保持稳定, 在气相色谱-质谱联用仪(GCNCI-MS)的色谱图中也没有检测到可能的脱溴代谢产物, 说明BDE209 没有发生显著的脱溴代谢作用.
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| 关 键 词： | 肠道微生物 体外实验 代谢 十溴联苯醚 |
| 收稿时间： | 2011-04-19 |
Study of the metabolism of decabromodiphenyl ether by human gut microbes |
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| ZHANG DongPing,ZHANG Fan,YU YingXin,WU MingHong,SHENG GuoYing, & FU JiaMo.Study of the metabolism of decabromodiphenyl ether by human gut microbes[J].Chinese Science Bulletin,2011,56(25):2139-2145. |
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| Authors: | ZHANG DongPing ZHANG Fan YU YingXin WU MingHong SHENG GuoYing & FU JiaMo |
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| Institution: | ZHANG DongPing1,ZHANG Fan1,YU YingXin1,WU MingHong2,SHENG GuoYing1,3 & FU JiaMo1,3 1 Institute of Environmental Pollution and Health,School of Environmental and Chemical Engineering,Shanghai University,Shanghai 200444,China,2 Institute of Applied Radiation,3 State Key Laboratory of Organic Geochemistry,Guangdong Key Laboratory of Environmental Resources Utilization and Protection,Guangzhou 510640,Chin... |
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| Abstract: | Decabromodiphenyl ether (BDE209) is a persistent organic pollutant that is used as brominated flame retardant. In organisms, it could be metabolized into compounds that have higher toxicity than BDE209 itself. In the present study, the metabolism of BDE209 was investigated by human gut microbes obtained from feces and gut microbes incubated using the Simulator of the Human Intestinal Microbial Ecosystem. The results showed that the concentrations of BDE209 in the incubation solution did not decease during i... |
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| Keywords: | gut microbes in vitro test metabolism decabromodiphenyl ether (BDE209) |
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