| CdTe/ZnS 量子点荧光可逆调控研究ctDNA 与吡柔比星的相互作用 |
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| 引用本文： | 闫曙光,刘绍璞,何佑秋.CdTe/ZnS 量子点荧光可逆调控研究ctDNA 与吡柔比星的相互作用[J].科学通报,2011,56(22):1804-1811. |
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| 作者姓名： | 闫曙光 刘绍璞 何佑秋 |
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| 作者单位： | 西南大学化学化工学院; |
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| 基金项目： | 国家自然科学基金资助项目(20875078) |
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| 摘 要： | 水相合成了谷胱甘肽修饰的CdTe/ZnS 量子点(GSH-CdTe/ZnS QDs). 从原子力显微镜照片可以看出, 合成的核壳型GSH-CdTe/ZnS QDs 具有良好的分散性. 当吡柔比星与GSH-CdTe/ZnS QDs 相互作用时, 吡柔比星吸附在GSH-CdTe/ZnS QDs 的表面, 通过光诱导电子转移的方式猝灭GSH-CdTe/ZnS QDs 的荧光. 然后向GSH-CdTe/ZnS QDs-吡柔比星体系中加入ctDNA, 吡柔比星从GSH-CdTe/ZnS QDs 表面脱落后嵌入ctDNA 双螺旋结构中, 光诱导电子转移过程被阻断, GSH-CdTe/ZnS QDs 的荧光恢复. 根据GSH-CdTe/ZnSQDs 荧光的猝灭和恢复, 实现了量子点荧光的可逆调控. 结合共振瑞利散射和紫外吸收光谱, 讨论了GSH-CdTe/ZnS QDs 吡柔比星-ctDNA 的相互作用机理, 建立了一种研究蒽醌类抗癌药物与核酸相互作用的光谱方法.
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| 关 键 词： | CdTe/ZnS 量子点 吡柔比星 ctDNA 荧光 |
| 收稿时间： | 2010-12-18 |
Reversible control of fluorescence on CdTe/ZnS quantum dots using the interaction between pirarubicin and ctDNA |
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| YAN ShuGuang,LIU ShaoPu & HE YouQiu School of Chemistry , Chemical Engineering,Southwest University,Chongqing ,China.Reversible control of fluorescence on CdTe/ZnS quantum dots using the interaction between pirarubicin and ctDNA[J].Chinese Science Bulletin,2011,56(22):1804-1811. |
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| Authors: | YAN ShuGuang LIU ShaoPu & HE YouQiu School of Chemistry Chemical Engineering Southwest University Chongqing China |
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| Institution: | YAN ShuGuang,LIU ShaoPu & HE YouQiu School of Chemistry and Chemical Engineering,Southwest University,Chongqing 400715,China |
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| Abstract: | Glutathione(GSH)-capped CdTe quantum dots(GSH-CdTe/ZnS QDs) were synthesized in aqueous solution.QD particle sizes and morphological characteristics were studied by atomic force microscope.The results indicate that a narrow size distribution and good dispersivity were obtained.Fluorescence(FL) of GSH-CdTe/ZnS QDs can be effectively quenched by binding of pirarubicin(THP) on their surfaces,enabling the photoinduced electron transfer(PET) process from the QDs to THP.Subsequent addition of ctDNA restored FL in... |
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| Keywords: | GSH-CdTe/ZnS QDs pirarubicin ctDNA fluorescence |
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