Age-related changes of the pattern of non-histone proteins in active and condensed fractions of mouse liver chromatin and hepatocarcinoma |
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| Authors: | Zh A Medvedev M N Medvedeva H M Crowne |
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| Institution: | (1) Genetics Division, National Institute for Medical Research, Mill Hill, NW7 1AA London, (England) |
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| Abstract: | Summary Electrophoretic analysis of histones and non-histone acid-soluble proteins in active (nuclease sensitive) and inactive chromatin from liver of young and old CBA mice and in age-related hepatocarcinomas showed a higher ratio of NHP: histones in active chromatin in old cells. Some liver- and hepatoma-specific fractions of non-histone proteins have been identified as chromatin matrix proteins. |
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| Keywords: | Liver mouse aging nonhistone proteins chromatin hepatoma |
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