利用基因打靶技术研制人类疾病小鼠模型

宏伟的人类基因组计划的顺利实施使人类真正进入了功能基因组学研究的新时代 ,与日俱增的大量遗传信息正对生物医学的研究方式和医疗模式产生巨大的影响。发展和应用针对全基因组或全系统的高通量、大规模的整体实验手段 ,利用结构基因组学提供的信息和材料研究基因的功能将成为这个时代生物医学研究的主要特征。基因功能是在由细胞组成的多层次的复杂生命体中实现的 ,因此 ,功能基因组学的研究将会在极大程度上依赖于对模式生物的研究。小鼠作为被研究的脊椎动物 ,尤其具备作为哺乳动物的模式生物具有独特的优势 :首先小鼠是具有较短世代周…

Study of Human Disease Mouse Model by Gene Target

The functional genomics is coming of age after the anatomy of the human genome is completed . The dramatic increase in the amount of genomic information is having a tremendous impact on biomedical research and on the way that medical treatment is processed, the major task is how to dissert the function of genes using large-scale and systematic approaches. Since genes function in the complex living creatures made of cells , the study of functional genomics will largely rely on the research of model organisms. The mouse is the closest mammalian model organism to human. Compared with other organism,mouse has many advantanges,short lifecycle,close genome size (2.5 × 109 bp in mouse vs 2.9 × 109 bp in human),available whole genome sequences and many inbred strains, easy to breed and maitain in lab. The most importantly, the genetic information of mouse gene could be modified in vivo by transgenic and gene targeting approaches.The mouse science is changing the modern biology study in general.