Neuroendocrine effects of a non-steroidal compound of testicular origin |
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| Authors: | F Iturriza M R Carlini F Piva L Martini |
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| Institution: | (1) Departments of Endocrinology and of Pharmacology, University of Milano, via A. del Sarto 21, I-20129 Milano, (Italy);(2) Present address: Catedra  B de Embriologia e Histologia, Facultad de Ciencias Medicas, Universidad Nacional de la Plata, La Plata, Argentina;(3) Present address: Catedra de Farmacologia, Universidad Nacional de San Luis, San Luis, Argentina |
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| Abstract: | Summary The effects of the compound (+)-1,4-diphenylbutane-2,3-diol (DPB, synthetized in the testes) on gonadotropin secretion have been studied in castrated male rats. DPB, when injected subcutaneously, does not modify serum levels of LH and FSH. On the contrary, the local implantation of DPB in the median eminence of the hypothalamus results in a significant elevation of serum FSH. It is suggested that DPB may play a physiological role in the control of FSH release.This work has been supported by grants of the Ford Foundation, New York, and of the CNR, Biology of Reproduction Program, Rome. Kits for LH and FSH radioimmunoassay have been kindly provided by the Rat Pituitary Hormone Distribution Program of the National Institutes of Arthritis, Metabolism and Digestive Diseases of the National Institutes of Health. Diphenylbutane was a kind gift of Dr R. Neher of the Ciba-Geigy Laboratories, Basel, to Dr Iturriza. Thanks are also due to Mrs Paola Assi Brunone for her skilful technical assistance. |
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