| 健胃胶囊的药效学研究 |
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| 引用本文： | 罗瑛,吴志利.健胃胶囊的药效学研究[J].江汉大学学报(自然科学版),2009,37(4):98-100. |
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| 作者姓名： | 罗瑛 吴志利 |
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| 作者单位： | 1. 江汉大学,附属医院药剂科,湖北,武汉,430015
2. 湖北中医学院,管理系,湖北,武汉,430061 |
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| 摘 要： | 目的:探讨健胃胶囊对试验动物幽门结扎型溃疡、胃肠排空及镇痛的作用机理,为临床应用提供依据.方法:采用适当剂量灌胃给药的方法,随机分成4组(高剂量组、低剂量组、阳性对照组、阴性对照组),观察健胃胶囊对大鼠幽门结扎型溃疡面的抑制率、对小鼠胃体内甲基橙残留量的影响与给予刺激剂15min内各组小鼠发生"扭体"反应次数.结果:健胃胶囊有明显抑制大鼠胃部幽门结扎型溃疡面、增加小鼠胃体甲基橙残留量、减少小鼠对刺激剂发生"扭体"反应次数.结论:健胃胶囊具有防止幽门结扎所致胃溃疡的发生、调节胃肠蠕动功能以及明显镇痛作用.
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| 关 键 词： | 健胃胶囊 药效学 幽门结扎型溃疡 胃肠排空 镇痛 |
Pharmacodynamics of Jianwei Capsule |
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| LUO Yin,WU Zhi-li.Pharmacodynamics of Jianwei Capsule[J].Journal of Jianghan University:Natural Sciences,2009,37(4):98-100. |
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| Authors: | LUO Yin WU Zhi-li |
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| Institution: | LUO Yin, WU Zhi-li2 (1. Pharmacy Department, Affiliated Hospital of Jianghan University, Wuhan 430015, China; 2. Management Department, Hubei College of Traditional Chinese Medicine, Wuhan 430061, China) |
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| Abstract: | Objective： To explore the mechanism of Jianwei capsule on the pyloric ligature ulcer, the gastrointestinal emptying and analgesia. Methods： Oraladministration, and randomly divides the objective rats into 4 groups （high dosages, low dosages, positive control, negative control）, observing the inhibitory activity ofpyloric ligature ulcer by Jianwei capsule, the remaining amount of methyl orange and ＂twisting body＂ reaction times in 15 mins. Results： Jianwei capsule can prevent ulcer from ligaturing pyloric, enhance the remaining amount of methyl orange and reduce ＂twisting body＂ reaction times. Conclusions： Jianwei capsule can prevent ulcer from ligaturing pyloric, adjust gastrointestinal emptying and eliminate pain. |
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| Keywords: | Jianwei capsule pharmacodynamics pyloric ligature ulcer gastrointestinal emptying analgesia |
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