Fluorescence response of acridine orange to changes in pH gradients across liposome membranes |
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Authors: | A A Cools L H M Janssen |
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Institution: | (1) Department of Pharmaceutical Chemistry, State University of Utrecht, Catharijnesingel 60, NL-3511 GH Utrecht, (The Netherlands) |
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Abstract: | Summary The influence that changes in proton distribution have on the fluorescence of acridine orange was examined using negatively charged liposomes. Our results indicate that at least two mechanisms are involved: distribution of the probe between the internal aqueous phase of the liposomes and the outside medium, and binding of the probe to the liposome membranes. |
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Keywords: | Acridine orange fluorescent probe pH gradient fluorescence quenching liposomes |
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