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| 半枝莲多糖对小鼠S180肉瘤抑制作用的研究 | |
| 引用本文： | 袁辉,李春江,马淑霞,夏玲洋.半枝莲多糖对小鼠S180肉瘤抑制作用的研究[J].哈尔滨商业大学学报(自然科学版),2012,28(4):396-398. |
| 作者姓名： | 袁辉 李春江 马淑霞 夏玲洋 |
| 作者单位： | 1. 牡丹江医学院机能学教研室,黑龙江牡丹江157011;佳木斯大学微生物学教研室,黑龙江佳木斯154007 2. 佳木斯大学微生物学教研室,黑龙江佳木斯,154007 3. 牡丹江医学院附属二院,黑龙江牡丹江,157011 |
| 摘 要： | 探讨半枝莲多糖对体内S180肉瘤肿瘤抑制作用及相关机制.采用动物移植性肿瘤实验观察半枝莲多糖对小鼠体内肿瘤细胞生长的影响,ELISA法检测对荷瘤小鼠外周血血清中白细胞介素-2和干扰素-α质量浓度的影响.结果显示,半枝莲多糖对S180肉瘤生长的抑制率以中剂量为佳;各剂量组均对脾脏指数有显著性差异,能够提高S180荷瘤小鼠外周血血清中白细胞介素-2及干扰素-α的质量浓度,但中剂量最为显著,表明半枝莲多糖在小鼠体内具有抑制S180肉瘤的作用. |
| 关 键 词： | 半枝莲多糖 抗肿瘤 白细胞介素-2 干扰素-α |
Inhibition effects of Scutellaria barbata D.Don polysaccharides on mice bearing S180 tumor |
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| YUAN Hui , LI Chun-jiang , MA Shu-xia , XIA Ling-yang.Inhibition effects of Scutellaria barbata D.Don polysaccharides on mice bearing S180 tumor[J].Journal of Harbin University of Commerce :Natural Sciences Edition,2012,28(4):396-398. | |
| Authors: | YUAN Hui LI Chun-jiang MA Shu-xia XIA Ling-yang |
| Institution: | 1.Department of Kinesiology,Mudanjiang Medical University,Mudanjiang 157011,China; 2.Department of Microbiology,Jiamusi Univerdity,Jiamusi 154007,China; 3.The Second Affiliated Hospital of Mudanjiang Medical University,Mudanjiang 157011,China) |
| Abstract: | This paper studied on the antitumor effect of Scutellaria barbata D.Don polyaccharides(SBP) on mice bearing S180 tumor.The effect of SBP on tumor growth and IL-2 INF-content were detected by ELISA detection method.The result showed that SBP could inhibit the growth of S180 and the effect of middle dose group was the best.Meanwhile,SBP could improve IL-2 and INF-α activity.This indicated that SBP could inhibit tumor S180 growth. |
| Keywords: | Scutellaria barbata D Don polysaccharides antitumor IL-2 IFN-α |
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