Oxygen consumption and biosynthetic function in perfused liver from rats at different stages of development |
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| Authors: | M P Mollica S Iossa G Liverini S Soboll |
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| Institution: | (1) Department of General and Environmental Physiology, University of Naples ‘Federico II’, Via Mezzocannone 8, I-80134 Napoli (Italy), Fax +39 81 542 4848, e-mail: susiossa@unina.it, IT;(2) Institute of Physiological Chemistry I, University of Düsseldorf (Germany), DE |
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| Abstract: | Changes in mitochondrial function were studied in perfused liver from rats aged 24 – 365 days. Oxygen consumption together
with the rates of gluconeogenesis, urea synthesis and ketogenesis were determined. Basal mitochondrial respiration as well
as the ability of the liver to synthesize glucose, urea and ketone bodies declined from 24- to 365-day-old rats. On the other
hand, on transition from 24 to 60 days the liver oxidation rate of hexanoate, sorbitol and glycerol is enhanced, but not of
ketone bodies or palmitate. Our results show that the transition from weaning to middle age is accompanied by defined changes
in hepatic substrate oxidation. From the observed time course of the decrease in basal and substrate-stimulated oxygen consumption,
it is concluded that in rat liver cells a decline in respiratory chain function, long-chain fatty acid and ketone body metabolism,
gluconeogenesis and ureogenesis occurs at a relatively early life stage.
Received 19 June 1998; received after revision 11 September 1998; accepted 11 September 1998 |
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| Keywords: | , Liver perfusion, oxygen consumption, gluconeogenesis, ureogenesis, ketone bodies, |
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