| 脯氨酰胺催化的不对称直接Aldol反应 |
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| 引用本文： | 王雪莲,刘全忠. 脯氨酰胺催化的不对称直接Aldol反应[J]. 西华师范大学学报(哲学社会科学版), 2008, 29(2): 173-177 |
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| 作者姓名： | 王雪莲 刘全忠 |
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| 作者单位： | 西华师范大学化学化工学院,四川南充637002 |
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| 摘 要： | Boc保护的L-脯氨酸与Suzuki偶联得到的联苯衍生的胺化合物反应，经过脱去Boc保护基得到脯氨酰胺催化剂，该催化剂与三氟乙酸组合可有效的催化芳香醛和酮的不对称直接Aldol反应，最高得到了91％的产率和87％的对映体过量值．
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| 关 键 词： | Suzuki偶联 脯氨酰胺 有机催化 不对称 直接Aldol反应 |
L-Prolinamide Catalysted Asymmetric Direct Aldol Reaction |
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| WANG Xue-lian,LIU Quan-zhong. L-Prolinamide Catalysted Asymmetric Direct Aldol Reaction[J]. Journal of China West Normal University:Natural Science Edition, 2008, 29(2): 173-177 |
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| Authors: | WANG Xue-lian LIU Quan-zhong |
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| Affiliation: | WANG Xue-lian,LIU Quan-zhong(College of Chemistry , Chemical Engineering,China West Normal University,Nanchong 637002,China) |
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| Abstract: | An enantioselective Aldol reaction was catalyzed by prolinamide derived from the Boc protected L-proline and 2'-aminobiphenyl-2-ol.20 mol % of the catalyst in combination with 5 mol % of trifluoracetic acid which was found to be effective catalyst in the direct aldol reaction of ketones with aldehydes,affording the coreesponding product in the yield of up to 91% and good enantioselectivity up to 87% ee. |
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| Keywords: | Suzuki cross-coupling prolinamide asymmetric direct Aldol reaction |
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