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Proton-induced dismutation of superoxide in aprotic media by bile pigments

Authors:	J M Ribó J -A Farrera J Claret

Institution:	(1) Department de Química Orgànica, Facultat de Química, Universitat de Barcelona, c/ Martí i Franquès 1, E-08028 Barcelona, Catalunya, (Spain);(2) Department de Química Fisica, Facultat de Química, Universitat de Barcelona, c/ Martí i Franquès 1, E-08028 Barcelona, Catalunya, (Spain)

Abstract:	Summary Cyclic voltammetry of molecular oxygen in aprotic media (dimethylformamide) and in the presence of bilirubin and other bile pigments shows that superoxide anion ( $O_{\mathop 2\limits^. }^ -$ ) undergoes proton-induced dismutation. Lactam hydrogens of bile pigments are sufficiently acid to induce $O_{\mathop 2\limits^. }^ -$ disproportionation to O₂ and H₂O₂. Because of its characteristic lipophilic behavior, a biological role for natural bilirubin similar to that of other non-enzymatic lipophilic scavengers of $O_{\mathop 2\limits^. }^ -$ is suggested.

Keywords:	Bile pigments bilirubin superoxide dismution superoxide scavenger
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