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| 新型含吡啶基手性配体的合成 | |
| 作者单位： | ;1.德宏职业学院医技系;2.云南大学教育部自然资源药物化学重点实验室 |
| 摘 要： | 改进了高收率、高选择性的手性叔丁基亚磺酰亚胺与2-吡啶基格氏试剂的不对称加成方法,合成了11个含吡啶基胺类手性配体,建立了手性叔丁基亚磺酰亚胺与2-吡啶基格氏试剂的不对称加成立体构型的预测模型. |
| 关 键 词： | 吡啶 手性配体 叔丁基亚磺酰胺 不对称合成 |
Synthesis of some novel pyridine-based chiral ligands |
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| Affiliation: | ,Department of Medical Technology,Dehong Vocational College,Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education,Yunnan University |
| Abstract: | The addition of 2- pyridyl Grignard reagents to chiral tert- butyl sulfinimines was developed in high yields and excellent diastereoselectivities. Eleven chiral 2- pyridyl amines were synthesized via this addition. A model was established to predict the configuration of this addition. |
| Keywords: | pyridine chiral ligand tert-butanesulfinamide asymmetric synthesis |
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