| 1H-3-正丙基-5-吡唑羧酸乙酯的合成 |
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| 引用本文： | 徐宝财,周智明,俞海.1H-3-正丙基-5-吡唑羧酸乙酯的合成[J].北京工商大学学报(自然科学版),2002,20(4):11-13,35. |
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| 作者姓名： | 徐宝财 周智明 俞海 |
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| 作者单位： | 1. 北京工商大学,化学与环境工程学院,北京,100037
2. 北京理工大学,化工与环境工程学院,北京,100081 |
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| 摘 要： | 2-戊酮和草酸二乙酯在醇钠溶液中发生 Claisen酯缩合反应 ,制得的δ-庚酮酸乙酯 -β-烯醇钠盐收率为 69.2 % ,该钠盐与水合肼及硫酸肼反应制得 1 H- 3-正丙基 - 5 -吡唑羧酸乙酯 ,粗产品收率为 1 0 0 % .通过正交实验及单因素实验研究了反应的较佳合成工艺条件 ,用红外光谱对产品进行了结构鉴定 .
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| 关 键 词： | 2-戊酮 δ-庚酮酸乙酯-β-烯醇钠盐 1H-3-正丙基-5-吡唑羧酸乙酯 |
| 文章编号： | 1671-1513(2002)04-0011-03 |
SYNTHESIS OF 1H-3-n-PROPYL PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER |
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| XU Bao cai ,ZHOU Zhi ming ,YU Hai.SYNTHESIS OF 1H-3-n-PROPYL PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER[J].Journal of Beijing Technology and Business University:Natural Science Edition,2002,20(4):11-13,35. |
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| Authors: | XU Bao cai ZHOU Zhi ming YU Hai |
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| Institution: | XU Bao cai 1,ZHOU Zhi ming 2,YU Hai 1 |
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| Abstract: | The Claisen condensation of 2 pentanone with diethyloxalate yielded sodium 1 ethoxycarbonyl 3 oxo hexanolate. Treatment of this sodium compound with the mixture of hydrazine hydrate and hydrazine sulfate solution gave 1H 3 n propyl pyrazole 5 carboxylic acid ethyl ester. The effective conditions of each step were acquired through orthogonal test or single factor test,and the reaction mechanism was also studied. The structures of the products were identified by analysis of IR spectrometry. |
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| Keywords: | pentanone Sodium 1 ethoxycarbonyl 3 oxo hexanolate 1H 3 n propyl pyrazole 5 carboxylic acid ethyl ester |
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