| Pickering乳液法原位制备载药磁性SiO_2空心球及缓释性能 |
| |
| 引用本文： | 王志琰,毋伟,张魁,陈建峰,张鹏远.Pickering乳液法原位制备载药磁性SiO_2空心球及缓释性能[J].北京化工大学学报(自然科学版),2010,37(3):110-114. |
| |
| 作者姓名： | 王志琰 毋伟 张魁 陈建峰 张鹏远 |
| |
| 作者单位： | 北京化工大学 化学工程学院， 北京100029 |
| |
| 摘 要： | 采用共沉淀法制备纳米Fe3O4颗粒,然后通过Pickering乳液模板法原位将布洛芬和纳米Fe3O4颗粒包覆在SiO2空心球中,制备出载药磁性SiO2空心球,对其组成、结构及药物释放性能进行了表征。研究结果表明:载药磁性SiO2空心球粒径大小平均为2μm,壁厚约为240 nm,内含布洛芬;原位载药可使空心球的壁厚增加;该材料适合用作药物的载体,具有缓释效果。
|
| 关 键 词： | Pickering乳液 磁性SiO2空心球 纳米Fe3O4 缓释 |
In situ preparation and characterizations of drug-loaded magnetic hollow silica microspheres by a pickering emulsion based route |
| |
| WANG ZhiYan,WU Wei,ZHANG Kui,CHEN JianFeng,ZHANG PengYuan.In situ preparation and characterizations of drug-loaded magnetic hollow silica microspheres by a pickering emulsion based route[J].Journal of Beijing University of Chemical Technology,2010,37(3):110-114. |
| |
| Authors: | WANG ZhiYan WU Wei ZHANG Kui CHEN JianFeng ZHANG PengYuan |
| |
| Institution: | WANG ZhiYan WU Wei ZHANG Kui CHEN JianFeng ZHANG PengYuan(College of Chemical Engineering,Beijing University of Chemical Technology,Beijing 100029,China) |
| |
| Abstract: | Nano-Fe3O4 particles have been prepared by chemical co-precipitation. Drug-loaded magnetic hollow silica microspheres (MHSM) were synthesized by an in-situ Picketing emulsion template method, where Ibuprofen and nano-Fe3O4 particles were absorbed in the hollow silica microspheres. The composition, structure and drug release property for as-synthesized material were characterized. The drug-loaded MHSM have an average size of 2μm and shell thickness of 240nm with a smooth outer surface and contain Ibuprofen. The shell thickness is increased by the in-situ loading drug, and the MHSM is effective as a drug carrier having a slow-release effect. |
| |
| Keywords: | Pickering emulsion magnetic hollow silica micospheres nano-Fe3O4 release |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《北京化工大学学报(自然科学版)》浏览原始摘要信息 |
| 点击此处可从《北京化工大学学报(自然科学版)》下载免费的PDF全文 |
