| 外消旋环氧化合物的水解动力学拆分研究 |
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| 引用本文： | 许苗云,黄道伟,刘惠娴,张 越.外消旋环氧化合物的水解动力学拆分研究[J].河北科技大学学报,2012,33(1):23-26,31. |
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| 作者姓名： | 许苗云 黄道伟 刘惠娴 张 越 |
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| 作者单位： | 河北科技大学化学与制药工程学院,河北石家庄,050018 |
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| 摘 要： | 外消旋环己二胺与L-(+)-酒石酸反应得化合物1,化合物1与3,5-二叔丁基水杨醛缩合,得到手性配体(化合物2),化合物2与Co(OAc)2.4H2O反应生成Salen-Co(Ⅱ)催化剂,然后经氧化得到Salen-Co(Ⅲ)(OAc)催化剂。末端环氧化合物在Salen-Co(Ⅲ)(OAc)催化下进行水解动力学拆分,所得的手性二醇ee值达到99.7%。
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| 关 键 词： | 外消旋环己二胺 3 5-二叔丁基水杨醛 水解动力学拆分 手性二醇 |
| 收稿时间： | 2011/7/1 0:00:00 |
| 修稿时间： | 2011/11/22 0:00:00 |
Hydrolysis kinetic resolution of racemic epoxides |
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| XU Miao-yun,HUANG Dao-wei,LIU Hui-xian and ZHANG Yue.Hydrolysis kinetic resolution of racemic epoxides[J].Journal of Hebei University of Science and Technology,2012,33(1):23-26,31. |
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| Authors: | XU Miao-yun HUANG Dao-wei LIU Hui-xian and ZHANG Yue |
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| Institution: | (College of Chemical and Pharmaceutical Engineering,Hebei University of Science and Technology,Shijiazhuang Hebei 050018,China) |
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| Abstract: | Product 1 is produced by reaction of racemic diaminocyclohexane with L-(+)-tartric acid,then it is condensed with 3,5-di-tert-butyl salicylaldehyde to give chiral Ligand 2,after which 2 reacts with Co(OAc)2·4H2O,and then it is converted to Salen-Co(Ⅲ)(OAc) by oxidation.Research in hydrolytic kinetic resolution of racemic terminal epoxides by Salen-Co(Ⅲ)(OAc) catalyst is conducted,and the ee value of chiral diol is of up to 99.7%. |
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| Keywords: | racemic diaminocyclohexane 3 5-di-tert-butyl salicylaldehyde hydrolysis kinetic resolution chiral diol |
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