| N-叔丁氧羰基-O-苄基-L-丝氨酸合成方法的改进 |
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| 引用本文： | 陶卫国.N-叔丁氧羰基-O-苄基-L-丝氨酸合成方法的改进[J].西华师范大学学报(哲学社会科学版),2009,30(2):209-210. |
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| 作者姓名： | 陶卫国 |
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| 作者单位： | 西华师范大学化学化工学院,四川南充637002 |
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| 摘 要： | 对文献报道和工业制备N-叔丁氧羰基-O-苄基-L-丝氨酸的方法进行了改进，以叔戊醇钠代替NaH和Na／NH3作为碱处理N-叔丁氧羰基-L-丝氨酸后，再与苄溴在温和条件下反应制得了N-叔丁氧羰基-O-苄基-L-丝氨酸，产率为53％．反应过程中不产生氢气．因此，该方法更安全，适合工业化生产．
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| 关 键 词： | 有机合成 N-叔丁氧羰基-O-苄基-L-丝氨酸 叔戊醇钠 N-叔丁氧羰基-L-丝氨酸 苄溴 |
Modification to Synthesis of N-(tert-Butoxycarbonyl)-O-Benzyl-L-Serine |
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| TAO Wei-guo.Modification to Synthesis of N-(tert-Butoxycarbonyl)-O-Benzyl-L-Serine[J].Journal of China West Normal University:Natural Science Edition,2009,30(2):209-210. |
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| Authors: | TAO Wei-guo |
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| Institution: | College of Chemistry and Chemical Engineering;China West Normal University;Nanchong 637002;China |
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| Abstract: | A facile method was developed to synthesize N-(tert-Butoxycarbonyl)-O-benzyl-L-serine with a yield rate of 53% by using sodium tert-pentoxide as a base for the reaction between N-(tert-Butoxycarbonyl)-L-serine and benzyl bromide under mild conditions.Furthermore,no hydrogen was released from the reaction,and thus the modified method is much safer than the reported ever,and suitable for industrial production of N-(tert-Butoxycarbonyl)-O-benzyl-L-serine. |
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| Keywords: | organic synthesis N-（ tert-Butoxycarbonyl）-O-benzyl-L-serine sodium tert-pentoxide N-（ tert-Bu-toxycarbonyl） -L-serine benzyl bromide |
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