Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages. |
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| Authors: | P Mombaerts A R Clarke M A Rudnicki J Iacomini S Itohara J J Lafaille L Wang Y Ichikawa R Jaenisch M L Hooper |
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| Institution: | Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, Massachusetts. |
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| Abstract: | Analysis of mice carrying mutant T-cell antigen receptor (TCR) genes indicates that TCR-beta gene rearrangement or expression is critical for the differentiation of CD4-CD8- thymocytes to CD4+CD8+ thymocytes, as well as for the expansion of the pool of CD4+CD8+ cells. TCR-alpha is irrelevant in these developmental processes. The development of gamma delta T cells does not depend on either TCR-alpha or TCR-beta. |
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