| DNA甲基化在肿瘤形成中的作用（综述） |
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| 引用本文： | 赵迎社,付步银.DNA甲基化在肿瘤形成中的作用（综述）[J].暨南大学学报,2001,22(4):54-57. |
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| 作者姓名： | 赵迎社 付步银 |
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| 作者单位： | 1. 暨南大学医学院生化教研室
2. 暨南大学医学院第一附属医院口腔科, |
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| 摘 要： | DNA甲基化改变是肿瘤细胞中常见的现象，DNA甲基化与肿瘤的发生有密切关系。从以下几方面对此做一综述。（1）简介哺乳动物细胞的DNA甲基化；（2）DNA甲基化与肿瘤基因突变；（3）肿瘤DNA甲基化的基因外作用，其中包括：原癌基因的低甲基化和抑癌基因的高甲基化。
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| 关 键 词： | 肿瘤 DNA甲基化 癌基因 抑癌基因 发病机制 细胞癌变 分子生物学 |
| 文章编号： | 1000-9965(2001)04-0054-04 |
Role of DNA methylation in carcinogenesis |
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| ZHAO Ying-she ,FU Bu-ying.Role of DNA methylation in carcinogenesis[J].Journal of Jinan University(Natural Science & Medicine Edition),2001,22(4):54-57. |
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| Authors: | ZHAO Ying-she FU Bu-ying |
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| Institution: | ZHAO Ying-she 1,FU Bu-ying 2 |
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| Abstract: | Alterations in DNA methylation are very common in cancer cells and are capable of directly modifying carcinogenesis. In this review, following topics are involved: (1) Introduction of DNA methylation in mammals. (2) DNA methylation and mutation in cancer. (3) The epigenetic role of DNA methylation in cancer that include hypomethylation of proto-oncogenes and hypermethylation of tumor suppressor genes. KH+3mmD |
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| Keywords: | tumor DNA methylation oncogene tumor suppressor gene |
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