Intracerebroventricular angiotensin II increases arterial blood pressure in rhesus monkeys by stimulation of pituitary hormones and the sympathetic nervous system |
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| Authors: | B. A. Schölkens W. Jung W. Rascher R. Dietz D. Ganten |
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| Affiliation: | (1) Hoechst AG, D-6230 Frankfurt a.M. 80, (Federal Republic of Germany);(2) Department of Pharmacology, University of Heidelberg, D-6900 Heidelberg, (Federal Republic of Germany) |
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| Abstract: | ![]()
Summary Intracerebroventricular injections of angiotensin II in anesthetized rhesus monkeys increase systemic blood pressure and heart rate. These effects are accompanied by an increase in plasma ADH, cortisol, adrenaline and noradrenaline. Angiotensin II may participate in central mechanisms of blood pressure regulation by its stimulatory effect on the sympathetic nervous system, on ADH and on ACTH release in primates. |
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