Glutathione and gamma-glutamyl cycle enzymes in rat mammary gland

The main enzymes of the gamma-glutamyl cycle during the lactogenic cycle in rat mammary gland were studied. A significant increase was found in all of them with the onset of lactogenesis. The effect of methionine sulfoximine on reduced glutathione concentration was studied in tissue slices of lactating mammary gland. The findings suggest that this compound effects glutathione synthesis by inhibiting gamma-glutamylcysteine synthetase.