Handheld optical coherence tomography device for photodynamic therapy |
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| Authors: | TianShi Wang ChengMing Wang NaiYan Huang Jian Zhang Ying Gu Ping Xue |
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| Institution: | [1]State Key Laboratory of Low-dimensional Quantum Physics and Laboratory of Atomic and Molecular Nanosciences, Department of Physics, Tsinghua University, Beijing 100084, China [2]Department of Laser Medicine, Chinese PLA General Hospital, Beijing 100853, China [3]School of Electronic Engineering, Tianjin University of Technology and Education, Tianjin 300222, China |
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| Abstract: | Photodynamic therapy (PDT) is a very effective treatment for port wine stains (PWS). To guide and assess PDT treatment, a
handheld optical coherence tomography (OCT) probe was designed for real-time imaging of the PWS patient. The system uses a
light source with a center wavelength of 1310 nm, −3 dB bandwidth of 90 nm and an optical power of 9 mW. The system also has
a spatial resolution of 8 μm (lateral) × 7 μm (axial), an imaging rate of 4 frames per second, and a 102 dB sensitivity. We
then demonstrate that the OCT imaging system can clearly distinguish between normal and PWS tissues. Therefore, the system
can provide valuable guidance for PDT treatment. |
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| Keywords: | optical coherence tomography photodynamic therapy port-wine stain |
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