| 99mTc-MAMA-HA与99mTcN-MAMA-HA的制备及生物性能的比较 |
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| 引用本文： | 吴战宏,王学斌,李至敏.99mTc-MAMA-HA与99mTcN-MAMA-HA的制备及生物性能的比较[J].北京师范大学学报(自然科学版),2002,38(6):776-781. |
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| 作者姓名： | 吴战宏 王学斌 李至敏 |
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| 作者单位： | 北京师范大学化学系,100875,北京 |
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| 基金项目： | 北京师范大学校科研和教改项目;; |
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| 摘 要： | 制备了2种脂肪酸标记物99mTc-MAMA-HA和99mTcN-MAMA-HA,改进了标记方法,放化纯均大于90%;对标记物进行了小鼠的生物分布实验,结果表明二者都有一定的心肌摄取,99mTc-MAMA-HA的心肌摄取要好于99mTcN-MAMA-HA,而后者的心肌滞留要好于前者,这说明99mTcN的引入明显改变了99mTc-MAMA-HA的生物分布.
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| 关 键 词： | 心肌代谢显像剂 99mTc-MAMA-HA 99mTcN-MAMA-HA 生物分布 |
| 修稿时间： | 2002年5月27日 |
THE PREPARATION AND BIOLOGICAL PROPERTIES OF 99mTc-MAMA-HA AND 99mTcN-MAMA-HA |
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| Wu Zhanhong,Wang Xuebin,Li Zhimin.THE PREPARATION AND BIOLOGICAL PROPERTIES OF 99mTc-MAMA-HA AND 99mTcN-MAMA-HA[J].Journal of Beijing Normal University(Natural Science),2002,38(6):776-781. |
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| Authors: | Wu Zhanhong Wang Xuebin Li Zhimin |
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| Abstract: | mTc-MAMA-HA and 99mTcN-MAMA-HA are prepared respectively with labeling yield all above 90%. The biodistribution indicates that they all show appropriate uptake in heart, and the heart uptake of 99mTc-MAMA-HA is better than that of 99mTcN-MAMA-HA. But the latter exhibits slower elimination from the heart than the former. From the result of biodistribution, it is shown obviously that the introduction of 99mTcN core affects the biodistribution behavior of 99mTc-MAMA-HA. |
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| Keywords: | myocardial metabolic agent 99mTc-MAMA-HA 99mTcN-MAMA-HA biodistribution |
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