| Photosensitized splitting of cis-syn 1,3-dimethyluracil dimer by tryptophan and its peptides |
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| 作者姓名： | HEI Xiaoming SONG Qinhu LI Jing GUO Qingxiang |
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| 作者单位： | Department of Chemistry,University of Science and Technology of China,Hefei 230026,China,Department of Chemistry,University of Science and Technology of China,Hefei 230026,China,Department of Chemistry,University of Science and Technology of China,Hefei 230026,China,Department of Chemistry,University of Science and Technology of China,Hefei 230026,China |
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| 基金项目： | 国家自然科学基金，Special Fund for Doctoral Programme of the State Education Commission of China |
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| 摘 要： | Photosensitized splitting of cis-syn 1,3-dimethyluracil dimer by tryptophan (Trp) and its peptides (Trp-Tyr and Trp-Phe) is studied by fluorescence quenching experiments and irradiation experiments.It reveals that 1,3-dimethyluracil dimer is mainly split by e?-?aq resulting from two-photon ionization of Trp and its peptides under irradiation with light (λ>290 nm).Moreover,the excited singlet state of Trp and its peptides can transfer an electron to the dimer,which splits and gives two pyrimidines.In addition,because of its lower oxidative potential,the excited triplet state of Trp-Tyr can also split the dimer via transfering an electron to the dimer.
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| 关 键 词： | tryptophan cyclobutane dimethyluracil dimer DNA photoreactivation |
Photosensitized splitting of cis-syn 1,3-dimethyluracil dimer by tryptophan and its peptides |
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| HEI Xiaoming,SONG Qinhu,LI Jing,GUO Qingxiang.Photosensitized splitting of cis-syn 1,3-dimethyluracil dimer by tryptophan and its peptides[J].Progress in Natural Science,2004,14(5):453-458. |
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| Authors: | Hei Xiaoming Song Qinhua LI Jing Guo Qingxiang |
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| Institution: | Department of Chemistry,University of Science and Technology of China,Hefei 230026,China |
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| Abstract: | Photosensitized splitting of cis-syn 1,3-dimethyluracil dimer by tryptophan (Trp) and its peptides (Trp-Tyr and Trp-Phe) is studied by fluorescence quenching experiments and irradiation experiments.It reveals that 1,3-dimethyluracil dimer is mainly split by e-aq resulting from two-photon ionization of Trp and its peptides under irradiation with light (λ>290 nm).Moreover,the excited singlet state of Trp and its peptides can transfer an electron to the dimer,which splits and gives two pyrimidines.In addition,because of its lower oxidative potential,the excited triplet state of Trp-Tyr can also split the dimer via transfering an electron to the dimer. |
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| Keywords: | tryptophan cyclobutane dimethyluracil dimer DNA photoreactivation |
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