The protective effect of thiola against the genotoxic action of benzo(a)pyrene |
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| Authors: | D Galdean D Petrasincu P Alangiu S Ibric N Voiculetz |
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| Institution: | (1) Institute of Oncology, P.O. Box 1005, Bucharest, (Romania);(2) Institute Dr. I. Cantacuzino, P.O. Box 1005, Bucharest, (Romania) |
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| Abstract: | Summary The protective effect of Thiola against the genotoxicity, induced by benzo(a)pyrene, in vitro and in vivo, was investigated. By association of Thiola to benzo(a)pyrene a significant decrease of the numerical and structural chromosome aberrations and a reduction of the incidence of c-mitoses has been obtained in human diploid cells, i.e. human embryonic lung fibroblasts of the cell-line ICP-23, and C56Bl/6 mouse bone marrow cells. |
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| Keywords: | Chemoprophylaxis cancer prevention benzo(a)pyrene chromosomal aberration genotoxicity Thiola anticarcinogens |
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