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The location of the polio genome protein in viral RNAs and its implication for RNA synthesis. |
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| Authors: | A Nomoto B Detjen R Pozzatti E Wimmer |
| Abstract: | Evidence is presented that a small protein (VPg) is covalently attached to the 5'-terminal oligonucleotide VPg-pU-U-A-A-A-A-C-A-Gp of the polio genome, to nascent strands of the polio replicative intermediate and to poly(U) of minus strands. A model of polio RNA replication is proposed implicating VPg in initiation of RNA symthesis, possibly as primer. |
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