A mutation in stratifin is responsible for the repeated epilation (Er) phenotype in mice |
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Authors: | Herron Bruce J Liddell Rebecca A Parker April Grant Sarah Kinne Jennifer Fisher Jill K Siracusa Linda D |
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Institution: | Genomics Institute, Wadsworth Center, NYS Dept. of Health, 465 Jordan Road, Albany, New York 12180, USA. bherron@wadsworth.org |
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Abstract: | Stratifin (Sfn, also called 14-3-3sigma) is highly expressed in differentiating epidermis and mediates cell cycle arrest. Sfn is repressed in cancer, but its function during development is uncharacterized. We identified an insertion mutation in the gene Sfn in repeated epilation (Er) mutant mice by positional cloning. Er/+ mice expressed a truncated Sfn protein, which probably contributes to the defects in Er/Er and Er/+ epidermis and to cancer development in Er/+ mice. |
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