阿霉素微胶囊的制备及表征

采用三嵌段共聚物聚乳酸-聚乙二醇-聚乳酸（PLA-PEG-PLA）为载体，阿霉素为模型药物，通过双乳化溶剂蒸发法制备出阿霉素微胶囊，考察了稳定剂和制备条件对阿霉素微胶囊的性质及阿霉素的载药率和释放速率的影响。扫描电子显微镜和激光粒度测试表明，阿霉素微胶囊呈类球形或不完全球形，粒径大小为900nm左右。阿霉素微胶囊对阿霉素的包封率为35.7％。通过体外释药实验表明，阿霉素微胶囊可持续释药10天以上。

Preparation and characterization of doxorubicin-loaded microcapsules

Doxorubicin(DOX)-loaded poly(lactic acid)-poly(ethylene glycol)-poly(lactic acid)(PLA-PEG-PLA) microcapsules have been prepared by a double emulsion technique and characterized by dynamic laser light scattering,scanning electron microscopy(SEM) and confocal laser scanning microscopy(CLSM).SEM showed that the microcapsules had a size of ca.900 nm and smooth spherical surfaces.CLSM images directly verified that DOX was encapsulated into the microcapsules.The entrapment ratio of DOX in the capsules amounted to 35.7%.The effects of varying the preparation conditions on the microcapsule size and DOX encapsulation efficiency were also investigated.Drug release studies in a physiological environment indicated that the controlled release of DOX from the microcapsules could be sustained for over 10 days.