| 高纯度荧光素钠的制备工艺研究 |
| |
| 引用本文： | 高乾善,高光杰,胡建强,李福伟. 高纯度荧光素钠的制备工艺研究[J]. 山东科学, 2009, 22(2): 43-45 |
| |
| 作者姓名： | 高乾善 高光杰 胡建强 李福伟 |
| |
| 作者单位： | 1. 山东省分析测试中心,山东,济南,250014
2. 山东博士伦福瑞达制药有限公司,山东,济南,250101 |
| |
| 摘 要： | 本文介绍了一种制备高纯度荧光素钠的新工艺。利用荧光素钠盐在DMF中与乙酰氯酰化,得到荧光素二乙酸酯。荧光素二乙酸酯的易结晶性可使杂质得以分离,再经过皂化、酸化、成盐的过程制得高纯度的荧光素钠。与常规工艺比较,该工艺具有产率高、纯化效果好的特点。产品纯度大于99％,产率大于78％。
|
| 关 键 词： | 纯化 制备 荧光素二乙酸酯 荧光素钠 |
Research on Preparation of the High-Purity Fluorescein Sodium |
| |
| Gao Qian-shan,Gao Guang-jie,Hu Jian-qiang,Li Fu-wei. Research on Preparation of the High-Purity Fluorescein Sodium[J]. Shandong Science, 2009, 22(2): 43-45 |
| |
| Authors: | Gao Qian-shan Gao Guang-jie Hu Jian-qiang Li Fu-wei |
| |
| Affiliation: | 1.Shandong Analysis and Test Center;Jinan 250014;China;2.Shandong Bausch & Lomb Freda Pharmaceutical Co.;Ltd.;Jinan 250101;China |
| |
| Abstract: | We obtained fluorescein diacetate through the acylation reaction of fluorescein sodium in DMF and acetyl chloride.We applied its easy crystallinity to the separation of impurities.We then prepare high-purity fluorescein sodium by saponification,acidification and salification.The positives of the technique are higher production rate and higher purity,as compared with conventional techniques.Its purity greater than 99% and its productivity is greater than 78%. |
| |
| Keywords: | purification preparation fluorescein diacetate fluorescein sodium |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
