Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication |
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| Authors: | D McVey L Brizuela I Mohr D R Marshak Y Gluzman D Beach |
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| Affiliation: | Cold Spring Harbor Laboratory, New York 11724. |
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| Abstract: | Simian virus 40 large tumour antigen (T) is a replication origin binding protein required for viral DNA synthesis. Unphosphorylated T antigen is deficient in promoting DNA replication in vitro but can be activated by phosphorylation at residue threonine 124 by the cdc2 protein kinase. This observation demonstrates that T is regulated by phosphorylation and provides a model for cdc2 function in the control of DNA replication. |
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