| 头孢孟多酯钠的波谱学特征和结构确证 |
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| 引用本文： | 林云良,高红梅,李锋,魏祥玉,王志伟,姜海龙,王岱杰.头孢孟多酯钠的波谱学特征和结构确证[J].山东科学,2018,31(3):113-118. |
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| 作者姓名： | 林云良 高红梅 李锋 魏祥玉 王志伟 姜海龙 王岱杰 |
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| 作者单位： | 齐鲁工业大学（山东省科学院），山东省分析测试中心，山东 济南 250014 |
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| 基金项目： | 国家自然科学基金青年基金（21506119） |
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| 摘 要： | 建立了利用分析仪器确证头孢孟多酯钠化学结构的方法。通过元素分析仪分析头孢孟多酯钠的元素组成，并利用核磁共振（NMR）、质谱（MS）、红外光谱（IR）、紫外光谱（UV）对头孢孟多酯钠进行结构分析。通过解析确证，头孢孟多酯钠的结构为7-D-( 2-甲酰氧苯乙酰胺)-3-［(1-甲基-1H-四唑-5-基)巯甲基］-8-氧代-5-硫杂-1-氮杂双环4.2.0]辛-2-烯-2-甲酸盐。该方法准确可行，可为头孢孟多酯钠的结构鉴定提供依据。
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| 关 键 词： | 波谱学 波谱特征 头孢孟多酯钠 结构确证 |
| 收稿时间： | 2017-09-08 |
Spectroscopic characteristics and structural identification of cefamandole nafate |
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| LIN Yun-liang,GAO Hong-mei,LI Feng,WEI Xiang-yu,WANG Zhi-wei,JIANG Hai-long,WANG Dai-jie.Spectroscopic characteristics and structural identification of cefamandole nafate[J].Shandong Science,2018,31(3):113-118. |
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| Authors: | LIN Yun-liang GAO Hong-mei LI Feng WEI Xiang-yu WANG Zhi-wei JIANG Hai-long WANG Dai-jie |
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| Institution: | Shandong Analysis and Test Center, Qilu University of Technology(Shandong Academy of Sciences),Jinan 250014，China |
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| Abstract: | A method was established for the chemical structure determination of cefamandole nafate by analytical instruments. The elemental analyzer was used to analyze the elemental composition of cefamandole nafate, and nuclear magnetic resonance, mass spectrometry, infrared spectrometry and ultraviolet spectrometry were adopted to analyze the chemical structure of cefamandole nafate. The chemical structure of cefamandole nafate was confirmed to be sodium 7-D-(2-hydroxy-2phenylacetyl)amino]3-{(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo4.2.0]oct-2-ene-2-carboxylate. This method is accurate and practical, which can provide a comprehensive reference for the structural identification of cefamandole nafate. |
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| Keywords: | structural identification spectroscopic characteristics spectroscopy cefamandole nafate |
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