| The mobilization of rat’s mesenchymal stem cells into peripheral blood by LiCL and its potency differentiation |
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| 引用本文： | DENG Jun,ZOU ZhongMin,ZHOU TaoLi,AI GuoPing,WANG JunPing,DONG ShiWu,SU YongPing↑ Institute of Combined Injury,State Key Laboratory of Trauma,Burns and Combined Injury,Department of Preventive Medicine,Third Military Medical University,Chongqing ,China, Department of Pathogenic Biology,Third Military Medical University,Chongqing ,China.The mobilization of rat’s mesenchymal stem cells into peripheral blood by LiCL and its potency differentiation[J].中国科学通报(英文版),2008,53(17):2632-2638. |
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| 作者姓名： | DENG Jun ZOU ZhongMin ZHOU TaoLi AI GuoPing WANG JunPing DONG ShiWu SU YongPing↑ Institute of Combined Injury State Key Laboratory of Trauma Burns and Combined Injury |
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| 作者单位： | DENG Jun1，ZOU ZhongMin1，ZHOU TaoLi2，AI GuoPing1，WANG JunPing1，DONG ShiWu1，SU YongPing1↑ 1 Institute of Combined Injury，State Key Laboratory of Trauma，Burns and Combined Injury，Department of Preventive Medicine，Third Military Medical University，Chongqing 400038，China; 2 Department of Pathogenic Biology，Third Military Medical University，Chongqing 400038，China |
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| 基金项目： | Supported by the National Key Basic Research and Development Plan of China (Grant No. 2005CB522605) and Opening Project of State Key Laboratory of Trauma, Burn and Combined Injury (Grant No. SKLKF200809) |
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| 摘 要： | Mesenchymal stem cells （MSCs） are multipotent cells, which can differentiate into different tissues. It is still controversial whether MSCs can be isolated from adult peripheral blood （PB） under normal conditions and whether they can be mobilized in a way similar to that of hematopoieUc stem cells （HSCs）. In this study, rat MSCs circulating in the PB under normal conditions can be isolated and cultured, and MSCs from PB and BM can be mobilized by LiCL. The mobilized MSCs can be induced to differentiate into neuron by such factors as β-mercaptoethanol and supernatants of nerve cell cultures. The present study provides a broader perspective on the repair of neural trauma.
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| 关 键 词： | 间叶细胞干细胞 外周血 LiCL 动物实验 |
| 收稿时间： | 2007-12-20 |
| 修稿时间： | 2008-05-21 |
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