Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk |
| |
| Authors: | Jaeger Emma,Webb Emily,Howarth Kimberley,Carvajal-Carmona Luis,Rowan Andrew,Broderick Peter,Walther Axel,Spain Sarah,Pittman Alan,Kemp Zoe,Sullivan Kate,Heinimann Karl,Lubbe Steven,Domingo Enric,Barclay Ella,Martin Lynn,Gorman Maggie,Chandler Ian,Vijayakrishnan Jayaram,Wood Wendy,Papaemmanuil Elli,Penegar Steven,Qureshi Mobshra CORGI Consortium,Farrington Susan,Tenesa Albert,Cazier Jean-Baptiste,Kerr David,Gray Richard,Peto Julian,Dunlop Malcolm,Campbell Harry,Thomas Huw,Houlston Richard,Tomlinson Ian |
| |
| Affiliation: | Molecular and Population Genetics Laboratory, Cancer Research UK, London WC2A 3PX, UK. |
| |
| Abstract: | ![]()
We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 x 10(-14)). |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
