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Enantioselective direct aldol-type reaction of 4-hydroxycoumarin with ethyl trifluoropyruvate catalyzed by modified cinchona alkaloids |
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| Authors: | HaiLei Cui Kun Jiang YanKai Liu Wei Du YingChun Chen |
| Affiliation: | Key Laboratory of Drug-Targeting and Drug Deliver System of Ministry of Education, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China |
| Abstract: | A new enantioselective aldol-type reaction of 4-hydroxycoumarins and ethyl trifluoropyruvate has been developed. In the presence of (DHQD)2PHAL (5 mol%), ethyl trifluoropyruvate could react with various 4-hydroxycoumarins to afford novel 4-hydroxycoumarin derivatives containing a tertiary trifluoromethyl alcohol center in good yields with moderate enantioselectivities. |
| Keywords: | 4-hydroxycoumarin tertiary trifluoromethyl alcohol asymmtric synthesis cinchona alkaloid organocatalysts |
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