Chromosomal organization at the level of gene complexes |
| |
Authors: | Email author" target="_blank">Vivek?S?ChopraEmail author |
| |
Institution: | (1) Department of Molecular and Cell Biology, 585, Life Sciences Addition, University of California, Berkeley, CA 94720-3200, USA |
| |
Abstract: | Metazoan genomes primarily consist of non-coding DNA in comparison to coding regions. Non-coding fraction of the genome contains
cis-regulatory elements, which ensure that the genetic code is read properly at the right time and space during development.
Regulatory elements and their target genes define functional landscapes within the genome, and some developmentally important
genes evolve by keeping the genes involved in specification of common organs/tissues in clusters and are termed gene complex.
The clustering of genes involved in a common function may help in robust spatio-temporal gene expression. Gene complexes are
often found to be evolutionarily conserved, and the classic example is the hox complex. The evolutionary constraints seen
among gene complexes provide an ideal model system to understand cis and trans-regulation of gene function. This review will discuss the various characteristics of gene regulatory modules found within
gene complexes and how they can be characterized. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|