Skeletin immunoreactivity in peripheral nerves

Summary By use of monospecific antibodies against the cow heart intermediate filament protein, skeletin, an antigenic relationship between skeletin and neurofilament protein of peripheral nerves is demonstrated. Crossreactivity is also demonstrated in the filament-containing Schwann cells. The results are consistent with the existence of several subclasses of related intermediate-sized filament proteins.Acknowledgments. The skilful technical assistence of Mrs Elisabeth Rubing, Miss Inga Johansson, and Miss Marléne Lundström is gratefully acknowledged. This work was supported by grants from Lions Research Fund, the Swedish Medical Research Council (12X-3934) and the Faculty of Medicine, University of Umeå.