Kinetics of DNA repair synthesis in guinea-pig pancreatic slices following in vitro exposure to N-methyl-N-nitrosourethane |
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Authors: | Z M Iqbal S S Epstein |
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Institution: | (1) Environmental Health Programs, Case Western Reserve University School of Medicine, 44106 Cleveland, Ohio, USA |
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Abstract: | Summary In vitro exposure of guinea-pig pancreatic slices to NMUT resulted in an increase in hydroxyurea-insensitive3H-TdR incorporation into DNA; this represents DNA repair synthesis following NMUT-induced DNA damage. The kinetics of this hydroxyurea-insensitive3H-TdR incorporation suggest that the NMUT-induced DNA damage is largely repaired within 2 hours.Environmental Health Programs, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 (USA). These studies were supported by National Cancer Institute (Bethesda, Md., USA). Contract No. N01-CP-23284. Technical assistance of MS.Mary Majdan is gratefully acknowledged. |
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