阿司匹林双嘧达莫胃内漂浮片的药动学及相对生物利用度的研究

采用随机交叉分组实验设计,给6条家犬分别口服单剂量阿司匹林普通片、双嘧达莫缓释胶囊和阿司匹林双嘧达莫胃内漂浮片,以HPLC法测定血浆药物浓度,采用3P97药物动力学程序计算药动学参数,统计分析显示：参比制剂和受试制剂的阿司匹林各主要药动学参数均有显著性差异,双嘧达莫各主要药动学参数无显著性差异,阿司匹林双嘧达莫胃内漂浮片具有明显的缓释特征,生物利用度具有生物等效性．

Studies on Pharmacokinetics and Relative Bioavailability of Aspirin-dipyridamole Floating Tablets in Stomach

In a randomized two-way cross-over design, aspirin common tablets, dipyridamole sustained release capsules and aspirin-dipyridamole floating tablets, respectively, were given to 6 male dogs in po. A rapid and sensitive HPLC assay was used for determining the drug levels in plasma, the Pharmacokinetic parameters were computed by software program 3 P97. The statistical analysis showed that there were significant differences between the main Pharmacokinetic parameters of aspirin of reference and test preparations, but there were no significant differences between the main Pharmacokinetic parameters of dipyridamole of them, the aspirin-dipyridamole floating tablets were sustained, the bioavailability of them was bioequivalence.