The effect of cycloheximide on nuclear uH2A content |
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| Authors: | N. Dalay B. Kirdar E. Bermek |
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| Affiliation: | (1) Present address: Biofizik Bilim Dah, Istanbul Tip Fakültesi, çapa-Istabul, Turkey |
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| Abstract: | ![]()
Summary The effect of intraperitonal cycloheximide administration on acid-soluble rat liver chromatin proteins has been investigated by electrophoresis in acetic acid-urea polyacrylamide gels. A nonhistone protein, which migrates between oxidized histone H3 and histone H1 has been found tobe increased in amount following cycloheximide treatment. This protein seems to be identical with semihistone protein H24 (uH2A). A possible relationship of uH2A to the inhibition of rRNA synthesis is discussed.This work was supported by the Turkish Scientific and Technical Research Council (TUBITAK) Project No. TAG 339 |
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| Keywords: | Rat liver liver, rat chromatin, rat liver cycloheximide nonhistone protein |
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