| 基于最短路径的关键蛋白质识别研究 |
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| 引用本文： | 嘉泽宁,杨贵,郑文萍.基于最短路径的关键蛋白质识别研究[J].广西大学学报(自然科学版),2011,36(5):764-769. |
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| 作者姓名： | 嘉泽宁 杨贵 郑文萍 |
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| 作者单位： | 山西大学智能信息处理研究所,山西太原,030006 |
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| 基金项目： | 国家自然科学青年基金资助项目(60803034); 高等学校博士点基金资助项目(200801081017) |
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| 摘 要： | 关键蛋白质的识别有助于从系统水平上理解生命活动过程,基于蛋白质相互作用网络拓扑特征的关键蛋白质识别可以有效地提高识别精度和速度.通过蛋白质节点的最短路径数和点介数可以作为衡量其节点中心度的方法,但计算速度和计算规模有限.根据所预测蛋白质相互作用网络的特点,提出了基于最短路径技术的关键蛋白质识别方法,选择合理的识别阈值和...
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| 关 键 词： | 蛋白质相互作用网络 最短路径 关键蛋白质 介数 |
Shortest path-based identification of essential proteins |
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| JIA Ze-ning,YANG Gui,ZHENG Wen-ping.Shortest path-based identification of essential proteins[J].Journal of Guangxi University(Natural Science Edition),2011,36(5):764-769. |
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| Authors: | JIA Ze-ning YANG Gui ZHENG Wen-ping |
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| Institution: | JIA Ze-ning,YANG Gui,ZHENG Wen-ping(The Institute of Intelligent Information Processing,Shanxi University,Taiyuan 030006,China) |
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| Abstract: | Identification of essential protein contributes to understanding the living processes at the system level.The essential protein identification based on protein interaction network topology characteristics can improve the accuracy and speed of recognition effectively.The number of shortest paths which pass a protein node and the vertex betweenness can be used to measure the node centrality degree.However,the computing speed and the calculation scale are limited.According to the characteristics of a protein n... |
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| Keywords: | protein-protein interaction network shortest path essential protein betweenness |
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