Heparanase involvement in physiology and disease |
| |
| Authors: | N. J. Nasser |
| |
| Affiliation: | Department of Oncology, Shaare Zedek Medical Center, Jerusalem, Israel. nicola.nasser@gmail.com |
| |
| Abstract: | ![]()
Heparanase is an endoglycosidase that degrades heparan sulfate on the cell surface and extracellular matrix. The physiological functions of heparanase include heparan sulfate turnover, embryo development, hair growth, and wound healing. Heparanase is implicated in a variety of pathologies, such as tumor growth, angiogenesis, metastasis, inflammation, and glomerular diseases. Heparanase overexpression in a variety of malignant tumors suggests that it could be a target for anti-cancer therapy. |
| |
| Keywords: | . Cancer progression extracellular matrix heparin heparanase angiogenesis alternative splicing metastasis hypoxia |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
