| PTA/AOT自发形成囊泡作为药物载体的缓释性研究 |
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| 引用本文： | 安娅,胡长刚,张笑一.PTA/AOT自发形成囊泡作为药物载体的缓释性研究[J].贵州师范大学学报(自然科学版),2005,23(3):105-107,118. |
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| 作者姓名： | 安娅 胡长刚 张笑一 |
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| 作者单位： | 贵州师范大学,理学院,贵州,贵阳,550001 |
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| 基金项目： | 贵州省教育厅黔教科（2003,206）资助项目,贵州师范大学青年教师科研发展基金项目. |
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| 摘 要： | 用无毒的阳离子表面活性剂PTA与阴离子表面活性剂AOT的溶液自发形成囊泡,并将之作为阿司匹林药物的载体开展在模拟肠液及模拟胃液中的缓释性研究。结果表明,用该体系的囊泡包封药物在模拟肠液或模拟胃液中均有一定的缓释作用。但随着体系组成配比、药物包封量以及环境的不同,其缓释效果有所不同。
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| 关 键 词： | 囊泡 阿司匹林 缓释率 |
| 文章编号： | 1004-5570（2005）03-0105-03 |
| 收稿时间： | 2005-03-24 |
| 修稿时间： | 2005-03-24 |
Study on the release efficiency of vesicles spontaneously-formed from PTA / AOT as drug delivery |
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| AN Ya,HU Chang-gang,ZHANG Xiao-yi.Study on the release efficiency of vesicles spontaneously-formed from PTA / AOT as drug delivery[J].Journal of Guizhou Normal University(Natural Sciences),2005,23(3):105-107,118. |
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| Authors: | AN Ya HU Chang-gang ZHANG Xiao-yi |
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| Abstract: | Vesicles are formed from the complex system of cation suffactant PTA and anionic suffactant AOT. Researches have been carried out upon the release efficiency of aspirin contained in the vesicles in simulated intestinal and gastric fluid. The results show that it has certain sustained release effects that aspirin entrapped into PTA / AOT system in simulated intestinal and gastric fluid. But the sustained release effects are different, when the composition ratio of the system, entrapment quantity of the drug and the environment are changed. |
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| Keywords: | vesicles aspirin release efficiency |
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