| 正交设计法催化氢化制备2,4,5-三氨基-6-羟基嘧啶 |
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| 引用本文： | 黄永明,吕银祥,刘文达,黄月芳.正交设计法催化氢化制备2,4,5-三氨基-6-羟基嘧啶[J].复旦学报(自然科学版),2000,39(4):459-462. |
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| 作者姓名： | 黄永明 吕银祥 刘文达 黄月芳 |
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| 作者单位： | 1. 复旦大学化学系
2. 复旦大学测试中心 |
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| 摘 要： | 以Ｐｄ／Ｃ为催化剂直接催化氢化２，４－二氨基－６－羟基－５－基硝基嘧啶制备２，４，５－三氨基－６－羟基喀啶，采用正效设计方法考察了碱的浓度、溶剂、催化和量、温度、反应时间等反应的影响，收率在９０％以上。
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| 关 键 词： | 羟基嘧啶 催化剂 催化氢化 正交设计 |
Preparation of 6-Hydro-2,4,5-triaminopyrimidine by Using Orthogonal Design Test |
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| HUANG Yong-ming,LU Yin-xiang,LIU Wen-da,HUANG Yue-fang.Preparation of 6-Hydro-2,4,5-triaminopyrimidine by Using Orthogonal Design Test[J].Journal of Fudan University(Natural Science),2000,39(4):459-462. |
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| Authors: | HUANG Yong-ming LU Yin-xiang LIU Wen-da HUANG Yue-fang |
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| Institution: | 1.Department of Chemistry; 2.Research Center for Analysis and Measurement |
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| Abstract: | Hydroxy 2,4,5 triaminopyrimidine was prepared by the hydrogenation of 2,4 diamino 6 hydroxy 5 nitrosopyrimidine over Pd/C catalyst, the synthetic conditions were optimized by orthogonal design, the best result, over 90% yield was afforded. |
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| Keywords: | hydroxy 2 4 5 triaminopyrimidine Pd/C catalyst catalytic hydrogenation orthogonal design test |
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