| 1,6-二磷酸果糖对缺氧缺血性心、脑损害的保护作用(综述) |
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| 引用本文： | 赵小朋,柳国胜.1,6-二磷酸果糖对缺氧缺血性心、脑损害的保护作用(综述)[J].暨南大学学报,2003,24(4):91-95. |
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| 作者姓名： | 赵小朋 柳国胜 |
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| 作者单位： | 暨南大学附属第一医院儿科,广东,广州,510630 |
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| 摘 要： | 1，6-二磷酸果糖(FDP)是存在于一切活细胞内的糖代谢中间产物。细胞缺氧时，外源性FDP可透过细胞膜进入到细胞内直接供能，并可阻止Ca^2 内流，减少氧自由基的产生、稳定细胞膜，及减少细胞凋亡。多数研究认为FDP对缺氧缺血引起的心、脑损伤具有保护作用，但也有不同的观点。因此有必要进一步临床验证，为FDP在这方面的应用提供有价值的理论依据。
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| 关 键 词： | 1，6-二磷酸果糖 脑损伤 心肌损伤 |
| 文章编号： | 1000-9965(2003)04-0091-05 |
| 修稿时间： | 2003年2月24日 |
The protective effect of FDP on the hypoxic and ischemic injury of heart and brain (A review) |
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| ZHAO Xiao-peng,LIU Guo-sheng.The protective effect of FDP on the hypoxic and ischemic injury of heart and brain (A review)[J].Journal of Jinan University(Natural Science & Medicine Edition),2003,24(4):91-95. |
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| Authors: | ZHAO Xiao-peng LIU Guo-sheng |
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| Abstract: | FDP is an intermediate product of glucose metabolization which exists in all cells alive. when cell has insufficient oxygen supply, ectogenic FDP can come into cells and provide energe directly, and also can prevent Ca~(++) flowing into the cell, reduce the production of oxygen free-radical, stabilize membrane and decrease the aptosis. lots of research have proved that FDP has protective effect on heart and brain injury caused by hypoxia and ischemia, but there is also different opinion. So further clinical validation is needed to provide theory for it's application. |
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| Keywords: | FDP brain injury cardiac muscle injury |
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