Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen |
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Authors: | W Driever G Thoma C Nüsslein-Volhard |
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Institution: | Max-Planck-Institut für Entwicklungsbiologie, Abteilung Genetik, Tübingen, FRG. |
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Abstract: | The maternal gene bicoid is a key component of the system that determines the pattern of the anterior half of Drosophila embryos. The bicoid protein forms a concentration gradient in early embryos, and is known to bind DNA. Specific binding sites are now shown to confer expression in a region of the embryo that depends on their affinity for bicoid protein: sites of high affinity allow expression further down the bicoid protein gradient than sites of low affinity. |
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