Increased release of tumour cells by collagenase at acid pH: A possible mechanism for metastasis |
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| Authors: | G. A. Turner |
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| Affiliation: | (1) Royal Victoria Infirmary, University Department of Clinical Biochemistry, NE1 4LP Newcastle upon Tyne, (England);(2) Present address: Department Experimental Pathology, Roswell Park Memorial Institute, 666 Elm Street, 14263 Buffalo, (New York, USA) |
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| Abstract: | ![]()
Summary The ability of collagenase to disaggregate a solid metastasizing lymphosarcoma has been shown to considerably increase with reducing environmental pH. It is suggested that this effect may be operating in vivo to release cells from a primary tumour. |
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