Some observations on the effect of Ro 7-1051 on Trypanosoma cruzi,particularly in cell culture |
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| Authors: | S Yoneda E Kimura Beatriz Ribas Castellani |
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| Institution: | (1) Department of Histology and Embryology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, (Brazil);(2) Present address: Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, (Brazil);(3) Present address: Post-Graduate of Microbiology, Institute of Chemistry, University of São Paulo, São Paulo, (Brazil) |
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| Abstract: | Summary The drug Ro 7-1051 showed a deleterious effect on the intracellular and extracellular forms of Trypanosoma cruzi represented by nuclear pyknosis, fragmentation and lysis of parasites and by its reduced susceptibility to infection.Acknowledgments. The authors are deeply thankful to Roche Products for supplying the drug and for valuable information. The authors are also grateful to Prof. Nelson Villa for criticism and to Miss edna Bertin for technical assistance |
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