T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens |
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| Authors: | H R MacDonald R Schneider R K Lees R C Howe H Acha-Orbea H Festenstein R M Zinkernagel H Hengartner |
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| Institution: | Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland. |
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| Abstract: | T lymphocytes reactive with the product of the Mlsa-allele of the minor lymphocyte stimulating (Mls) locus use a predominant T-cell receptor beta-chain variable gene segment (V beta 6). Such V beta 6-bearing T cells are selectively eliminated in the thymus of Mlsa-bearing mice, consistent with a model in which tolerance to self antigens is achieved by clonal deletion. |
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