野鸦椿水提物对大鼠抗肝纤维化的影响

50只大鼠随机分为正常组、模型组、秋水仙碱组以及野鸦椿高、低剂量组，除正常组外余灌胃给予CCl4每周2次，共8周造成慢性肝纤维化模型，第4周开始秋水仙碱组给秋水仙碱0.1 mg/kg，野鸦椿高、低剂量组分别给野鸦椿水提物1 mL/kg和0.2 mL/kg，连续5周，模型组及对照组给等体积生理盐水.给药结束后，处死动物取血、分离血清，检测HA、LN及PⅢP 含量.结果发现，野鸦椿高、低剂量组HA、LN、PⅢP均明显低于模型组，高剂量组HA、LN浓度与秋水仙碱组没有显著性差异，PⅢP则高于秋水仙碱组，而低于低剂量组.结果表明：野鸦椿水提物具有抗慢性肝纤维化的作用，并存在一定的量效关系.

Effects of Water Extracts from Euscaphis Japonica on Hepatic Fibrosis in Rats

Fifty rats were randomly divided into normal group,model group,Colchicine group,high and low dose Euscaphis Japonica groups.Hepatic fibrosis models were established by CCl4 twice a week via intragastric administration for 8 weeks except normal groups.Colchicine（0.1 mg/kg） had been administered to the Colchicine group,water extracts from Euscaphis Japonica（1 mL/kg or 0.2 mL/kg） had been administered to the high and low dose Euscaphis Japonica groups from the fourth week.Five weeks later,all rats were killed to draw blood and separate serum,and then all serum samples were analysed.The results showed that the levels of HA,LN and PⅢP in the high and low dose Euscaphis Japonica groups were significantly lower than those in the model groups;there were no significant differences of HA,LN concentration between the high dose group and Colchicine group;and the level of PⅢP in high dose group was higher then that in Colchicine group but lower then in low dose group.It is concluded that water extracts from Euscaphis Japonica can be used to treat hepatic fibrosis in a dose-dependent manner.