| Surface modification of nanogold particles in DNA detection with quartz crystal microbalance |
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| 作者姓名： | LIUTao TANGJi＇an HANMeimei JIANGLong |
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| 作者单位： | [1]KeyLaboratoryofColloidandInterfaceScience,InstituteofChemistry,ChineseAcademyofSciences,Beijing100080,China [2]ChemistryEngineeringDepartment,HarbinEngineeringUniversity,Harbin150001,China |
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| 基金项目： | 国家自然科学基金，国家重点基础研究发展计划(973计划) |
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| 摘 要： | Nanogold particles in different sizes, from 5 to 60 nm, were utilized to modify the surface of the quartz crystal microbalance (QCM). It was found that the gold-particle size of the modified QCM affects both the amount of the immobilization of the probe on the surface of QCM and the hybridization rate of the target DNA. 20 nm was determined to be the optimal size for the surface modification and it can maximally increase the sensitivity of the DNA detection.
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| 关 键 词： | 石英晶体微量天平 表面修复 DNA探测 金 纳米粒子 |
| 收稿时间： | 2002-09-29 |
| 修稿时间： | 2003-01-08 |
Surface modification of nanogold particles in DNA detection with quartz crystal microbalance |
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| Tao Liu,Ji'an Tang,Meimei Han,Long Jiang.Surface modification of nanogold particles in DNA detection with quartz crystal microbalance[J].Chinese Science Bulletin,2003,48(9):873-875. |
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| Authors: | Tao Liu Ji'an Tang Meimei Han Long Jiang |
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| Institution: | e-mail: leotaol974@ yahoo.com |
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| Abstract: | Nanogold particles in different sizes, from 5 to 60 nm, were utilized to modify the surface of the quartz crystal microbalance (QCM). It was found that the gold-particle size of the modified QCM affects both the amount of the immobilization of the probe on the surface of QCM and the hybridization rate of the target DNA. 20 nm was determined to be the optimal size for the surface modification and it can maximally increase the sensitivity of the DNA detection. |
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| Keywords: | gold nanoparticle DNA detection quartz crystal micro-balance |
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